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Vibration analysis of a simply supported beam under moving mass based on moving finite element method

Zhuchao YE, Huaihai CHEN,

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 4,   Pages 397-400 doi: 10.1007/s11465-009-0044-7

Abstract: simply supported beam for a moving mass (MM).The MFE method treats the moving mass as a moving part of the entire system, so that the transverse inertialeffects caused by the moving mass may easily be taken into account.displacement is obtained via a Newmark-β method; the effects of the velocity and weight of the MMThe numerical examples show that the inertial effects of the MM significantly affect the transverse responses

Keywords： simply supported beam     moving mass (MM)     transverse vibration     moving finite element (MFE)    

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Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral disc degeneration in vivo

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 415-420 doi: 10.1007/s11684-009-0072-z

Abstract: The aim of this study was to investigate the inhibitory effects of recombinant adenovirus vector carrying tissue inhibitor of metalloproteinase-3 (RAdTIMP-3) against degeneration of rabbit intervertebral disc. Thirty Japanese white rabbits of 4 months old were randomly divided into 5 groups. Mild or moderate rabbit lumbar disc degeneration model was constructed with the controllable axial loading device by imposing 98N pressure at the discs for 2 weeks. Various doses of virus were injected into the degenerated discs as follows: 20μL of normal saline in group 1; 20μL of RAd66 (an empty adenovirus vector, 1.0×10OPU/mL) in group 2; and 20, 10, and 5μL of RAdTIMP-3 (1.0×10OPU/mL) in groups 3, 4, and 5, respectively. Two weeks after the injection, the discs were collected for investigations, including assessment of degeneration degrees according to the Thompson’s grading system, reverse-transcription polymerase chain reaction (RT-PCR) assay for TIMP-3 gene, Safranin O-Fast green staining, and immunohistochemical staining for TIMP-3 and type II collagen. According to Thompson’s criteria, the degeneration of groups 3, 4, and 5, especially group 3, was alleviated as compared with groups 1 and 2. RT-PCR revealed that the expression of TIMP-3 in groups 3, 4, and 5, especially in group 3, was significantly enhanced as compared with group 1 (<0.01). Both Safranin O-Fast green staining and type II collagen staining demonstrated better reserved integrity of disc matrix in groups 3, 4, and 5 than in groups 1 and 2. TIMP-3 staining exhibited an obvious increase of positive-staining rate in groups 3, 4, and 5 as compared with group 1. The positive-staining rate in group 3 (79.42%±1.35%) was about 3times that of group 1 (25.47%±5.46%, <0.01). RAdTIMP-3 can effectively protect the matrix of rabbit intervertebral disc against overloading-induced degeneration in a dose-dependent manner, resulting in the alleviation of disc degeneration.

Keywords： tissue inhibitor of metalloproteinase-3     intervertebral disc     rabbit     gene therapy    

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Role of stair-climbing test in predicting postoperative cardiopulmonary complications in elderly patients with biliary diseases

Pei-Tu REN BM, Bao-Chun LU MM, Zhi-Liang CHEN MM, Hong FU MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 77-81 doi: 10.1007/s11684-010-0005-x

Abstract: One hundred and twenty-six patients above 80 years old with biliary diseases undergoing operations in Shaoxing People’s Hospital from Jan. 2002 to Jan. 2007 were analyzed retrospectively. All patients performed a preoperative stair-climbing test, and the risks for cardiopulmonary €complications were evaluated with pair-matching and linear correlations analysis between stair-climbing height (h) and left ventricular ejective factor (EF), forced vital capacity (FVC) and forced expiratory volume in one second (FEV). There was a significant difference in the incidence of cardiopulmonary complications among different stair-climbing heights. Stair-climbing heights were positively related with EF, FVC and FEV. This suggests that the stair-climbing test is an effective and simple method for predicting cardiopulmonary complications in elderly patients with biliary diseases.

Keywords： biliary disease     cardiopulmonary complication     stair-climbing test    

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Dynamic prediction of moving trajectory in pipe jacking: GRU-based deep learning framework

Frontiers of Structural and Civil Engineering   Pages 994-1010 doi: 10.1007/s11709-023-0942-5

Abstract: The moving trajectory of the pipe-jacking machine (PJM), which primarily determines the end quality ofgated recurrent unit (GRU)-based deep learning framework is proposed herein to dynamically predict the movingThe results show that the proposed framework can dynamically and precisely predict the PJM moving trajectory, with a minimum mean absolute error and root mean squared error (RMSE) of 0.1904 and 0.5011 mmThe proposed framework is expected to provide an effective decision support for moving trajectory control

Keywords： dynamic prediction     moving trajectory     pipe jacking     GRU     deep learning    

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Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 336-340 doi: 10.1007/s11684-009-0053-2

Abstract: Lanthanum salt is a prescription drug, but its underlying functions and mechanisms are not fully understood currently. To explore the potential therapeutic value of , cytotoxicity test was applied to investigate its effects on cell proliferation. Furthermore, we observed its influence on pro-oncogene by reverse transcription polymerase chain reaction (RT-PCR). In MCF-7 cell line, repressed cell proliferation at high concentration but had no significant inhibition effect on cell growth at low concentration. However, we observed that repressed transcription at a low concentration. This may suggest that is a potent drug to inhibit the high expression of in carcinoma cells and play a clue for inhibiting the growth and invasion of tumor.

Keywords： proliferation     c-met     invasion     lanthanum chloride    

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Design and analysis of the gripper mechanism based on generalized parallel mechanisms with configurable moving

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 4,   Pages 765-781 doi: 10.1007/s11465-021-0655-1

Abstract: Generalized parallel mechanisms with a configurable moving platform have become popular in the researchgrasping motion) gripper mechanisms based on the generalized parallel mechanisms with a configurable movingFirst, the configurable moving platform, which is a closed loop, is designed for grasping manipulation

Keywords： generalized parallel mechanism     configurable moving platform     gripper mechanism     type synthesis     kinematic    

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Multi-harmonic forced vibration and resonance of simple beams to moving vehicles

Frontiers of Structural and Civil Engineering   Pages 981-993 doi: 10.1007/s11709-023-0979-5

Abstract: This study modeled the moving-vehicle-induced forcing excitation on a single-span prismatic bridge asThe analysis revealed that a moving load induces high-harmonic forced resonance amplification when themoving speed is low.sprung-mass oscillator vehicle model.induce notable variation of the modal oscillation harmonic structure for the cases that vehicle of small mass

Keywords： forced vibration     linear Euler beam     moving load     harmonic structure     frequency modulation     end restraints    

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Effect of pirfenidone on renal tubulointerstitial fibrosis

Dixin LI MM , Hongbing ZENG MD , Chunyang JI MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 316-322 doi: 10.1007/s11684-009-0045-2

Abstract: Renal tubulointerstitial fibrosis (TIF) is the common end stage of various chronic renal diseases, and pirfenidone (PFD) is a novel, broad-spectrum anti-fibrotic compound but little is known about its effect and mechanism of action on renal TIF. In this work, we employed a unilateral ureteral obstruction (UUO) rat model to investigate the apoptosis of renal tubular epithelial cells (RTC) after PFD treatment. Thirty-five Sprague Dawley (SD) rats were randomized into three groups: sham-operated group (=7), UUO group (=14) and PFD group (=14). All rats were sacrificed at day 7 or 14 after operation. Renal histology was studied by using periodic acid schiff reagent (PAS) and Masson trichromic stain (MASSON); apoptosis was detected by terminal deoxynucleotide transferase-mediated dUTP-biotin nick end-labeling (TUNEL); tubular caspase-3 expression was assessed by immunohistochemistry. The content of malondialdehyde (MDA) and total activity of superoxide dismutase (T-SOD) in the renal cortex was determined by chemical colorimetry method. TIF, apoptosis of RTC, tubular expression of caspase-3 and the content of MDA were increased in the UUO group compared with those in the sham-operated group, and were ameliorated significantly by PFD treatment (<0.05). The activity of SOD was decreased in the UUO group, but was improved by PFD treatment (<0.05). Our results showed that PFD could ameliorate TIF in the UUO group, and the possible mechanism was by reducing the apoptosis of RTC, which involved oxidative stress and caspase-3.

Keywords： pirfenidone     apoptosis     caspase 3     oxidative stress    

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Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 341-346 doi: 10.1007/s11684-009-0067-9

Abstract: Phosphatidylinositol 3-kinase (PI3K) is a crucial cell survival pathway implicated in tumorigenesis because of its role in stimulating cell proliferation and suppressing apoptosis. This study was to investigate the regulation of proliferation and apoptosis by LY294002, an inhibitor of PI3K in cervical cancer cells and the expression of FLICE-like inhibitory protein (c-FLIP) . Human cervical cancer HeLa cells were used in this experiment and cultured. The cultured cells were treated with LY294002 at different concentrations (10, 25, 50 and 100µmol/L) for 6, 12, 24, and 48h before harvesting for evaluation. Cell viability was measured by 3-(4,5)-dimethylthiazol(-2-y1)-3,5-di-phenyltetrazoliumbromide (MTT) assay. Apoptosis was analyzed by flow cytometry. The expression of c-FLIP was detected by Western blot. Cell viability was inhibited by LY294002 significantly (<0.05). Flow cytometry analysis revealed that cell apoptosis was significantly increased in the presence of LY294002 as compared with the control group. Although the expression of c-FLIP was increased in a short time, the expression of c-FLIP was markedly suppressed after the treatment of LY294002 for 48h. These results suggested that the PI3K/Akt signal pathway might be involved in the regulation of cell apoptosis in cervical cancer cells. Moreover, the regulation of c-FLIP expression through PI3K/Akt signal pathway in cervical cancer cells was observed .

Keywords： human cervical cancer cells     apoptosis     phosphatidylinositol 3-kinase (PI3K)/Akt     FLICE-like inhibitory protein    

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Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 271-276 doi: 10.1007/s11684-009-0054-1

Abstract: The aim of this paper is to investigate the relationship between hepatitis B virus (HBV) DNA levels during the course and the progression to cirrhosis with chronic hepatitis B. A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followed up for a median of 28 months. Compared with the patients without cirrhosis, the patients progressed to cirrhosis were older and with higher HBV-DNA levels at end point. However, there was no significant difference in cirrhosis progression between different HBV-DNA groups at baseline ( = 0.531). Kaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis ( = 0.019). The results of Cox model indicated that HBV-DNA levels at endpoint, stage of fibrosis, negative hepatitis B e antigen, and γ-glutamyl transpeptidase at baseline were independent risk factors of cirrhosis. The relative risk ratios were 1.898, 1.918, 8.976, and 1.006, respectively. Progression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up.

Keywords： hepatitis B     chronic     viral load     liver cirrhosis    

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The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 384-389 doi: 10.1007/s11684-009-0070-1

Abstract: In the present report, cyclin-dependent kinase1 (CDK1) siRNA was transfected into cells to silence the CDK1 gene expression and study its role in the cell cycle and cell apoptosis. The siRNA targeting CDK1 gene was chemically synthesized and transfected into Hela cells by lipofectamine 2000. The expression levels of CDK1 gene and protein were examined by real-time quantitative polymerase chain reaction (PCR) and Western blot, respectively. The cell cycle was analyzed by using DNA content analysis by flow cytometry. Cell apoptosis was detected by the Annexin V/PI method. The morphological changes of transfected cells were examined under the microscopy by Wright-Giemsa stain. CDK1 gene was successfully silenced by its siRNA, and the CDK1 protein expression level was decreased significantly, especially from 48thh to 60thh after transfection. The DNA content analysis showed that transfection of CDK1 siRNA led to cells accumulating in G/M phase. There was no significant difference in the apoptotic rate between transfected cells and the control cells after transfection of CDK1 siRNA for 48 or 60h. More double nucleus or multinucleus cells could be seen under the microscopy among the transfected cells. The decreased CDK1 expression by siRNA silencing gave rise to cell cycle arrest in G/M phase but did not induce apoptosis.

Keywords： cyclin-dependent kinase1     siRNA interference     cell cycle     apoptosis    

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The next step of community health construction: Training general practitioners and implementing health management

Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 134-138 doi: 10.1007/s11684-010-0041-6

Abstract: This article discusses the concept of health management and stresses that community health management should be the starting point of community health service, necessitating a paradigm shift from observing the treatment-oriented medical model to observing the prevention-and-health management-based medical model. Community health construction has entered a new phase, one which highlights the need to train general practitioners in practice-based life cycle health management. In addition, general practitioners should assume the mission of implementing community health management.

Keywords： community health     general practitioners     health management    

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A Flexible Moving Objects Segmentation Method

Zhao Yanling,Zhang Zhichao,Gao Zhenming,Zhang Qingchao

Strategic Study of CAE 2006, Volume 8, Issue 5,   Pages 84-87

Abstract:

The segmentation for moving pictures is important in content-based video encoding and video retrievalThe method of moving object segmentation is proposed with spatio-temporal threshold information.

Keywords： spatio-temporal     moving regions     moving objects     morphological gradient operator     flexibility    

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Effects of carrier-attached biofilm on oxygen transfer efficiency in a moving bed biofilm reactor

Yanling WEI,Xunfei YIN,Lu QI,Hongchen WANG,Yiwei GONG,Yaqian LUO

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 3,   Pages 569-577 doi: 10.1007/s11783-015-0822-x

Abstract: Three laboratory-scale moving bed biofilm reactors (MBBR) with different carrier filling ratios ranging

Keywords： carrier     biofilm     oxygen transfer efficiency     moving bed biofilm reactor    

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Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced diarrhea

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 470-474 doi: 10.1007/s11684-009-0077-7

Abstract: The aim of this paper was to observe the clinical effect of gentamycin combined with sodium bicarbonate for the prevention of irinotecan-induced diarrhea. A total of 98 patients with stage IV cancers were recruited and divided into a prevention group (52 patients) and a control group (46 patients). All patients received the chemotherapy including irinotecan. The prevention group received gentamycin and sodium bicarbonate before the use of irinotecan for 4 days; the control group did not receive any prevention. The use of gentamycin and sodium bicarbonate resulted in significantly higher stool pH ( < 0.001), while the incidence of diarrhea by irinotecan was reduced (prevention group 13.70% control group 34.83%; < 0.001). Gentamycin combined with sodium bicarbonate appears to be useful in preventing the diarrhea induced by irinotecan and reducing the dosage of loperamide and fluid replacement.

Keywords： irinotecan     diarrhea     gentamycin     sodium bicarbonate     prevention    

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Title Author Date Type Operation

Vibration analysis of a simply supported beam under moving mass based on moving finite element method

Zhuchao YE, Huaihai CHEN,

Journal Article

Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral disc degeneration in vivo

Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,

Journal Article

Role of stair-climbing test in predicting postoperative cardiopulmonary complications in elderly patients with biliary diseases

Pei-Tu REN BM, Bao-Chun LU MM, Zhi-Liang CHEN MM, Hong FU MM,

Journal Article

Dynamic prediction of moving trajectory in pipe jacking: GRU-based deep learning framework

Journal Article

Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

Journal Article

Design and analysis of the gripper mechanism based on generalized parallel mechanisms with configurable moving

Journal Article

Multi-harmonic forced vibration and resonance of simple beams to moving vehicles

Journal Article

Effect of pirfenidone on renal tubulointerstitial fibrosis

Dixin LI MM , Hongbing ZENG MD , Chunyang JI MM ,

Journal Article

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Journal Article

Correlation between viral load and liver cirrhosis in chronic hepatitis B patients

Lili LIU MM , Jiyao WANG MD , Weimin SHE MM ,

Journal Article

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo

Journal Article

The next step of community health construction: Training general practitioners and implementing health management

Kan ZHANG MM, Wei DONG MM, Ying-Yao CHEN MD,

Journal Article

A Flexible Moving Objects Segmentation Method

Zhao Yanling,Zhang Zhichao,Gao Zhenming,Zhang Qingchao

Journal Article

Effects of carrier-attached biofilm on oxygen transfer efficiency in a moving bed biofilm reactor

Yanling WEI,Xunfei YIN,Lu QI,Hongchen WANG,Yiwei GONG,Yaqian LUO

Journal Article

Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced diarrhea

Qi MEI MM, Zhe CAO MM, Hua XIONG MD, Yuan CHEN MD,

Journal Article